Beckman Coulter
Multisizer 4e
Coulter Coulter – Particle Size and Count Analyser
- Unparalleled sizing range of 0.2 – 1600 μm
- Advanced noise reduction system
- Patented digital pulse processing technology
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Key Features
Versatility
- Aperture sizes from 10 µm – 2000 µm in diameter for current & future needs
- Multiple aperture options & data overlay capability for analyzing complex samples over wide particle size distribution
Sample Detection
- Analyse materials in aqueous or non-aqueous solvents
- Ideal for biological or non-biological samples
- Detect particles regardless of material type or optical properties
Rapid Particle Counting
- Typical sampling rates up to 10,000 counts per second
- Detect & count particles from 0.2 µm – 1600 µm in diameter
- Sample volumes as small as 5 mL
Data Management
- Digital pulse data can be stored & re-analysed as needed
- CFR 21 Part 11 compliant software for audit control & security
- Variety of calibration beads & V-check validation controls
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Technical Specs
Particle Sizing RangeDiameter: 0.2 – 1,600 µm
Volume: 0.004 – 2.145 x 109 µm3Aperture Size10 – 2,000 µm (nominal diameter)
Measurement rangeExtended: 2 – 80% of aperture size
Standard: 2 – 60% aperture sizeMeasurement linearityDiameter: ± 1%
Volume: ± 3%Dynamic range (accuracy)Diameter: 1 : 40 (extended), 1 :30 (standard),
Volume: 1 : 64,000 (extended), 1: 27,000 (standard)Processor typeHigh speed signal digitalisation
Number of pulses measuredUp to 525,000 per analysis
ResolutionUser difined
Number of size classesUp to 400 for display of any selected measurement range
The number of classes and their width can be changed as neededPulse distribution dataX axis: time, registration sequence, pulse width
Y axis: diameter, volume or voltage corresopnding to pulse amplitude,
pulse width, mean diameter, volume, or voltage corresponding to pulse
amplitude, average pulse width, pulse distribution by widthParticle size distribution dataX axis: diameter, volume, surface area
Y axis: absolute number, percent content (%), number per ml, absolute volume, volume percentage (%) volume per ml, absolute surface area (%) surface area per mlSample registration mode:
total number of particles50 – 500,000 counts
Sample registration mode:
number of particles and
measurement of parameters10 – 100,000 counts
Sample registration mode:
time0.1 – 999 seconds with 10 ms increments
Standard registration time is 10 – 90 secondsSample registration mode:
volume50 – 2,000 µL
Dosage systemThe dosing pump with even suspension flow across the aperture and volume measurement, error – less than 0.5%
Electrolyte type:Aqueous and non-aqueous electrolyte solutions compatible with glass, fluoropolymers, fluoroelastomers and stainless steel
Aperture current strength range:30 – 6,000 µA with 0.2µA increments
Aperture current stability:± 0.4% of set value
Polarity errorLess than 0.5%
Compliance with standardsSoftware is 21 CFR part 11 compliant
Dimensions64 x 61 x 51 cm, weight 45 kg
Power supply requirements230 – 240 V ± 10%, 47 – 63 Hz
Power consumptionLess than 55 Watts
Fuses250 V, IEC (5×20 mm) with time delay, 2.0 A
Environmental requirementsThe instrument is intended for work in enclosed spaces
Working temperature: 5 – 40°C
Relative humidity: 30 – 85% without condensation -
Applications
Yeast
Beer
Protein
E. coli
Plant Cells
CAR-T Cells
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Capabilities
The Multisizer 4e particle sizer and counter is the most accurate and flexible particle characterization device available, boasting an unparalleled sizing range of 0.2 – 1600 μm. The new 10 μm Aperture allows users to study sub-cellular and micro-particles as small as 200 nm, while the advanced noise reduction system for small apertures improves measurement accuracy.
Generated data are processed using patented digital pulse processing technology and can be saved and later re-analyzed. This technology provides ultra high resolution and accuracy unattainable through any other technologies: detection of 1 particle in 1 ml of a sample with the optimal instrument configuration. Analysis results are not dependent on particle shape, structure, or optical properties.
It uses the Coulter principle to detect particles via electrical zone sensing, regardless of the particle’s nature or optical properties. This makes it an ideal tool for detecting and counting a wide variety of particles, such as:
- Mammalian cells
- Bacteria
- Yeast
- Abrasives
- Toner particles
- Cell aggregates
- Spheroids
- Large protein aggregates
Not sure if it’s the right instrument?
No worries, send us a sample and we will test it for you
Send a sample-
Outstanding service
I have been using Meritics for a number of years and they always provide outstanding service and support.
They have a rapid response turnarounds and are very knowledgeable of the techniques and products they provide.LeanneB-375
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Good service, very helpful
We use Meritics for the PM service and installation of all our FlowCams . Megan has been coming to our site for a number of years. She is very efficient in her work, but most of all Megan is very helpful. We have had issues with one of instruments after the install and Megan did her utmost to try and solve it while on site, even though it wasn’t solved Megan has been in contact with the supplier of the instrument to try and solve this problem for us.
SophieH-2201
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Job done in a friendly manner
Booking engineer visits is always easy. David Lowe, Meritics engineer is always very friendly.
ThierryN
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Service/calibration visit
Excellent service, arrived on time, polite, friendly and informative.
NathamM-270
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5 Stars
Excellent service from an excellent company. Would recommend them to anyone.
BarryH-480
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Good Service
David, our service engineer as usual was good at communicating and setting up the recent service appointment, he arrived on time, did the service promptly and informed me of any problems. Friendly and helpful
TomA-446
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Superb and prompt service
I have used this company through the laboratory I work for frequently. We specialise in soil analysis, and Meritics were chosen as they have extensive knowledge of the instruments we use. We have several laser particle diffraction analysers with a service contract, and service is always very prompt and meticulous….
JamesG-2483
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Good experience over two years
Meritics have covered the annual servicing of our Multisizer 4e instrument since we purchased it from them just over two years ago. The application scientist who performed the servicing was friendly, knowledgeable, and extremely helpful, happily answering a barrage of questions about how best to use and maintain the instrument. All my interactions with Meritics staff have been positive. I would happily recommend them.
RajG-62
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Fully committed to customer service
Service second to none, both units serviced and all questions answers by engineer while on site.
RichardA-786
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Highly recommend Meritics for equipment purchases and aftercare services
After owning one of our instruments for over 8 Years which was purchased from Meritics, it suffered its first breakdown. Upon contacting Meritics, I was instantly put through to an engineer who was very helpful. Upon inspection of the manual, it was decided that it would be more cost effective to have a Meritics engineer visit. The Meritics staff were very communicative and kept me up to date.
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Excellent Service
Lovely, friendly and extremely helpful. David and his team are always on call with advise and are very easy to work with and are always happy to help.
NaomiT-64
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Service of lab equipment
Excellent service. Friendly and professional service was provided in a timely manner to the expected standard.
NathanM-270
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Excellent
Excellent communication. Updates given well in advance. Very polite staff and engineers.
NathanM-270
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Multisizer 4e install at pharmaceutical company
2 people helped with the install of a Multisizer 4e. They were both very professional and friendly, answering any questions that I had. The installation was quick and the attention to good documentation practice was exceptional.
Chloel-9
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Service of Beckman Coulter instruments
Always a pleasure to welcome the Meritics service engineer, who is knowledgeable, personable and extremely competent.
NeilT-394
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Professional
Friendly and collaborative staff, provided a very good service.
SamK-403
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Professional, Customer-oriented, fast service
We had issues with one of the aperture tubes provided by Meritics on a Friday afternoon, while very pressed for a review deadline. Meritics handled our inquiries very fast and professionally and helped us out by shipping us their spare tube to use in the mean time free of charge, while we waited for our new tube to arrive. Communication was very pleasant.
VeerleB
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Very helpful and prompt
I emailed for some technical help and also to get some spares and both the engineer (David) and purchasing (Sophie) were very prompt to respond and helpful. We do have a service contract but I appreciated being able to email the engineer directly.
AlexH-474
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Excellent Service
Used Meritics to conduct particle size distribution by laser diffraction. Service as last time, is very quick, well priced and professional.
I would highly recommend
GavinR-101
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Excellent and Friendly Service
Always a pleasure to deal with the people at Meritics Ltd. They understand the importance of our work and the fact that our research projects have deadlines that need to be met. Consequently, problems are dealt with very quickly and professionally and they are willing to go that one step further to make sure their supply chain problems don’t become our problems. Thank you to the team for their support. It is greatly appreciated.
JanetH-255