Meritics Ltd

LS 13 320 XR is an easy-to-use laser diffraction analyser that yields fast, reliable particle size analysis data for dry and aqueous and non-aqueous samples.

From its dynamic range to its higher resolution, the LS 13320 XR offers specific, quantifiable improvements that benefit both the pharma and industrial markets.

Details matter. Small changes in material can result in big differences in finished product.

Your customers demand consistency and the new LS 13320 XR can help ensure that expectations are always met.
Building on the Beckman Coulter legacy of providing accurate, reproducible results, the LS 13320 XR features an expanded dynamic range and workflow optimised software to better meet the needs of high throughput laboratories.

We made big improvements so you can spot small differences.
The LS 13 320 XR boosts laser diffraction particle size analysis to the next level, with its enhanced PIDS technology and extended measurement range providing higher resolution and more accurate, reproducible results. You can measure a wider range of particles and detect smaller differences in samples more quickly and reliably. And new software with an intuitive interface provides data you need with only a few clicks.

Discover the most versatile and accurate particle sizing and counting analyser on the market.

The Multisizer 4e particle sizer and counter is the most accurate and flexible particle characterization device available, boasting an unparalleled sizing range of 0.2 − 1600 μm. The new 10 μm Aperture allows users to study sub-cellular and micro-particles as small as 200 nm, while the advanced noise reduction system for small apertures improves measurement accuracy.

Generated data are processed using patented digital pulse processing technology and can be saved and later re-analyzed. This technology provides ultra high resolution and accuracy unattainable through any other technologies: detection of 1 particle in 1 ml of a sample with the optimal instrument configuration. Analysis results are not dependent on particle shape, structure, or optical properties.

It uses the Coulter principle to detect particles via electrical zone sensing, regardless of the particle’s nature or optical properties. This makes it an ideal tool for detecting and counting a wide variety of particles, such as:
- Mammalian cells
- Bacteria
- Yeast
- Abrasives
- Toner particles
- Cell aggregates
- Spheroids
- Large protein aggregates

Flow Imaging Microscopy with Light Obscuration

For the first time ever, you can obtain Light Obscuration data to meet USP regulatory guidelines, and also verify your data with real images, all with a single instrument, and a single sample run. Our FlowCam LO instrument combines our patented flow imaging microscopy technology with an embedded light obscuration particle counter to provide you with the necessary data for USP regulations and validation with images.

In FlowCam LO, a single sample passes continuously through two flow cells. The first, uses FlowCam technology to capture digital images and the second, uses the light obscuration method to collect data for USP regulations.

While analysis with light obscuration is standard, the FDA has long made clear that size data alone, collected with light obscuration, is not adequate to ensure safe and effective drugs, and that it’s necessary to provide validation and imaging data using orthogonal methods. FlowCam LO has the orthogonal method built in.

FlowCam LO provides:
- USP <787/788> compliance data with light obscuration
- Flow imaging microscopy validation of particle types with images
- Identification of additional particles missed by light obscuration alone
- Greater understanding of drug product formulation

FlowCam 8000 Series

FlowCam 8000 series combines the benefits of digital imaging, flow cytometry, and microscopy into a single instrument. Count and analyse tens of thousands of particles per minute and see your subvisible particles with superior image quality.

Experience industry-leading particle analysis instrumentation based on digital imaging technology. FlowCam is the first automated particle analysis instrument to use digital imaging for measuring size and shape (including 40+ morphological characteristics) of microscopic particles in a fluid medium. With applications in oceanographic research, municipal water, biopharmaceutical formulations, chemicals, oil and gas, biofuels, and many other markets, FlowCam continues to lead the way in imaging particle analysis.

The FlowCam 8000 series represents the next generation FlowCam platform following the release of the VS.

System improvements include:
- Larger field of view and faster camera to provide increased data throughput
- Integrated auto-focus mechanism to simplify focusing and provide consistent, high-resolution images
- Redesigned optical path, high-powered laser and more sensitive PMTs to enhance fluorescence signal analysis
- Interchangeable quick-connect flow cell holder to streamline operation

FlowCam Specifications:
- Magnification: 20X, 10X, 4X, 2X
- Camera resolution: 1920×1200 pixels, available in colour and monochrome
- Minimum sample volume of 100 µl
- Autofocus capability
- Compatible with the ALH − Automated Liquid Handler
- Fluorescence trigger: excitation options (488nm, 532nm, 633nm) with 2 channel fluorescence detection
- Equipped with our image analysis software VisualSpreadsheet®

FlowCam Nano is the next-generation dynamic image analysis instrument for submicron particle imaging and sizing in real-time. FlowCam Nano extends subvisible particle analysis to detect objects between 300 nanometers and 2 micrometers − the smallest visible with light microscopy.

Use FlowCam Nano for early detection of aggregates and contaminant monitoring for protein formulations, nano-drug delivery systems, characterization of bacteria, bioprocess monitoring, and materials characterisation.

FlowCam Nano Benefits:
- Highest-quality images to detect and identify submicron particle types to inform product development and monitor product quality
- Obtain size, morphology, and relative concentrations of particles in the 300 nm to 2 µm size range that are too small to be detected by traditional Flow Imaging Microscopy
- Early detection of API aggregation and other forms of sample degradation that are prone to generating larger subvisible and visible particles
- Integrated, industry-leading VisualSpreadsheet® software with the unique ability to image, classify, and characterize nanoparticles in real-time
- Quickly and consistently perform instrument setup and data collection with the easy-to-use interface and autofocus technology

FlowCam Macro uses patented flow-imaging technology to image, count, and analyse particles from 300µm to 5mm.

Based on proven FlowCam dynamic imaging particle analysis technology and optimized for larger particles, FlowCam Macro provides rapid particle characterization that goes beyond just particle size. Direct, image-based measurements of more than 40 morphological characteristics enable differentiation of particle types in a heterogeneous mixture.

Applications include:
- Food & beverage characterisation
- Sphericity measurement of manufactured beads
- Fibre characterisation
- Polymers, crystals, powders and other chemicals particle analysis

FlowCam Macro offers:
- Measures particle size and shape − over 40 morphological measurements on each particle imaged.
- Provides superior image quality and image-based measurements − fast and accurate results you can see, backed by the quantitative data to prove it.
- Gives statistically relevant results quickly − allows you to look at tens of thousands of particles per minute.
- Allows automated, trainable, statistically-based pattern recognition − saves time by isolating different types of particles into categories and sub-populations.
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The new FlowCam 5000 is streamlined for rapid data acquisition and analysis.

As our most affordable instrument, the FlowCam 5000 is ideal for general monitoring applications, process-specific monitoring applications like drinking water utilities, as well as for aquatic research and educational institutions.

Using flow imaging microscopy, FlowCam instruments provide digital images that allow for rapid count, measurement, and identification of organisms and particles in a liquid sample.

With the FlowCam 5000 you can:
- Analyse freshwater and marine samples
- Calculate cell counts, concentration & biovolume
- Provide semi-automated classification of taxa
- Identify cyanobacteria, taste & odour algae, nuisance & filter clogging algae

FlowCam 5000 Specifications:
- Magnification: single objective (select one magnification: 2X, 4X, 10X, or 20X)
- Camera resolution: 1920 x 1200 pixels, available in colour and monochrome
- Minimum sample volume of 100 µl
- Manual focus capability
- Equipped with our image analysis software VisualSpreadsheet®

Applications
The FlowCam 5000 can be used for many different applications:
- Food and Beverage
- Cosmetics and Powders
- Paints, Coatings and Inks
- Plastics, Polymers, Rubbers and Adhesives
- Chemicals and Abrasives
- Oil and Gas
- Column Packing / Manufacturing Beads

Particle size and shape analysis 0.01 − 3,500 µm.

With its unique and innovative design, the Bettersizer Series (consisting of the Bettersizer S3 and the S3 Plus) combines the measurement methods of static light scattering and dynamic image analysis, thus offering a universal option for characterizing the size and shape of particles from the nanometre to the millimetre range.

Using the patented DLOIOS technology, even nanoparticles (from 10 nm onward) can reliably be characterized. The additional lens between the laser and the measurement chamber enables the detection of the backscattered light. The use of only one laser with the oblique incidence of light provides a continuous scattering spectrum with consistent wavelength and allows the detection in a continuous angle range up to 165°.

Since the maximal intensity of the scattered light of large particles can only be detected at very small angles, the classical static light scattering cannot analyse those particles sufficiently enough. The image analysis system of the Bettersizer S3 Plus enables, in contrast to other laser diffraction systems, the reliable detection of larger particles thanks to particle detection by the camera and thus allows realistic measurements up to 3.5 mm.

Thanks to the implemented dynamic image analysis, the most important shape parameters can be calculated from the individual particle images − aspect ratio, circularity, sharpness of edges, and others.

The shape analysis can be carried out simultaneously with the size analysis or independently. Thereby you can choose between two magnifications for image collection (Bettersizer S3 Plus: 0.5X and 10X).

The BeNano Series is the latest generation of nanoparticle size and zeta potential analysers designed by Bettersize Instruments. Dynamic light scattering (DLS), electrophoretic light scattering (ELS), and static light scattering (SLS) are integrated into the system to provide accurate measurements of particle size, zeta potential, and molecular weight. The BeNano Series is widely applied in academic and manufacturing processes of various fields including but not limited to: chemical engineering, pharmaceuticals, food and beverage, inks and pigments, and life science, etc.

The BeDensi B1-S is a bulk density tester designed for accurate and reliable measurements of various metal powders and pharmaceutical powders. It uses Scott capacity meter technology and is compliant with industry standards such as ISO 3923-2, ASTM B329, USP <616>, and EP 2.9.34. With its compact and durable design, the BeDensi B1-S is ideal for use in laboratories and production facilities. Whether you’re working with metal or pharmaceutical powders, the BeDensi B1-S is the perfect choice for precise and reliable bulk density measurements.

The 3P graviSorb is a fully automated, gravimetric, multi-sample, high load capacity, high resolution, and dynamic water vapor sorption analyser. It measures adsorption and desorption isotherms of water vapor both accurately and sensitively, including sorption kinetics, with minimal operator involvement. The weight of up to 12 samples is monitored and recorded as the relative humidity is automatically varied by blending dry carrier gas with a saturated gas stream. The carousel balance design of the 3P graviSorb allows increased analysis throughput by simultaneous investigation of up to 12 different samples, or 11 + 1 if one station is running an empty sample chamber or even a reference material for direct comparison. The 3P graviSorb is an ideal solution for the determination of water uptakes for research and quality assurance. The complete automatic measuring process together with the precise balance, broad climate range and user-friendly software make it the ideal instrument for high sample throughput with a minimum of costs and maintenance.

The 3P micro series includes fully automated volumetric sorption analyzers for measuring adsorption and desorption of Nitrogen and other non-corrosive gases on one (3P micro 100), two (3P micro 200) or three (3P micro 300) independent analysis stations.

The instruments can be fitted with a turbomolecular pump and low-pressure sensors for micropore analysis and Krypton physisorption. Depending on customer requests, the instruments can be equipped with only mesopore stations (A version), micro- and mesopore stations (B/B1 version) or only micropore stations (C/C1 version). Each analysis station has its own dosing manifold for optimal analysis duration. Regardless of the starting time, the analysis will take the same amount of time! Each analysis station comes with its own p0 cell with a dedicated pressure sensor. The stations are fully independent from one another, analysis can be started at any time.

The 3P micro 100 and 200 have two integrated separate degassing stations that can be operated parallel to the analysis stations. The three analysis stations of the 3P micro 300 can be used for in-situ sample preparation to avoid sample contamination.

The 3P surface DX is a fully automated gas sorption analyser with four parallel operating analysis stations for rapid BET surface area determination. The instrument operates without a vacuum system but works with the dynamic principle (flow method). Both Single- and Multipoint-BET measurements can be carried out reliably and in very short times suitable for production and quality control. Use of reference comparison methods keeps the detection time of adsorption peaks extremely short.

The mixSorb S series provides unique capabilities to investigate novel materials, like MOFs, COFs etc. by mixed gas adsorption. Novel materials are in the focus of research in recent last years. These materials can have very high selectivity’s due to their extraordinary surface chemistry and have to be investigated by mixed gas sorption for a deeper understanding of their sorption behaviour.

In contrast to the mixSorb L series, the mixSorb S series is designed for very small sample amounts (powders). Especially R&D groups have now the possibility to measure newly synthesized materials by complex dynamic sorption processes in a wide field of different gas- and gas/vapor-mixtures by using different parameters like pressure, temperature gas velocity/dwell times, cycle tests and much more. These experiments allow to get data, next to the effective adsorption performance, of kinetics, co-adsorption phenomenon or displacement effects, sorption selectivity’s, data of gas mixture adsorption and heat balance of the sorption process.

By using the available vapor option it is possible to work up to 2 completely independent evaporators to form fully automated individually gas/vapor mixtures fully automated. These data allow a profound look at the co-adsorption phenomenon or displacement effects.

The related modelling software 3P sim made it possible to calculate and to modify pure gas isotherms as well as breakthrough curves and to calculate the behaviour of gas/vapor-mixture equilibria.

Powder flow property measurements generally fall into two main categories: dynamic analysis and static analysis. Dynamic instruments measure powder flow properties as the test material is moving or is about to move.
Static instruments measure powder that is not moving and typically has been exposed to pressure. For a complete picture of a material’s flow behavior, both types of testers are required. For solving specific flow problems, usually one type of tester or test is required.
The Revolution Powder Analyser can measure your powder’s ability to flow, consolidate, granulate, cake, pack and fluidise by measuring the power, time and variances in power of your powder in a rotating drum. This data can be used to quantify your powder’s particle behaviour during process applications such as blending, tableting, mixing and transportation. The Revolution is both easy to load and automatic, eliminating the opportunity for human error.

The Evolution Powder Tester is an economical and easy-to-use powder flow tester that measures the unconfined yield strength (a critical flow property) of powders and granular materials.
The unconfined yield strength can be measured at one pressure or at many different pressures in order to create a flow function. The flow function presents the material’s gain in strength after more pressure had been applied to it.

The patent pending EVOLUTION Powder Tester measures a powder or granular material’s response to environmental stresses. The major stress on a material is pressure. The EPT measures a material’s response to pressure by applying pressure to the material and then measuring its resulting strength. This strength is known as the unconfined yield strength. If a powder is to flow, the force making the powder move must be greater than the unconfined yield strength.

Flowability is the capacity to move by flow that characterises powders, i.e. loose particulate solids, as well as fluids. If you need an affordable, easy-to-use method to measure the flow properties and bulk characteristics of your powder then you need to be aware of the Volution Powder Flow Tester.

The Volution Powder Flow Tester uses an annular shear cell to measure a powder’s response to consolidating pressure using the yield locus technique. This approach, in conjunction with the instrument’s heavy duty frame and drive system, allows the Volution Powder Flow Tester system to measure powder samples at pressures up to 250kPa (50kg force). This is around 6 times greater than other instruments, which are often more expensive as well.

The Moxi Z mini automated cell counter with new OS 4.4 gives you accurate results you can count on.

The Moxi Z OS 4.34 is the only automated cell counter that combines the gold standard Coulter Principle typically used in high-end cell counters with a patented thin-film sensor technology to allow for highly accurate and repeatable particle sizing and counting with a broad dynamic range (3 − 34 microns).

The Moxi Z OS 4.4 also provides a reagent-less assessment of culture health for monodisperse mammalian cultures using a proprietary algorithm to report a Moxi Population Index (MPI).

This revolutionary ultra-small instrument offers characterisation of particulates in a wide variety of common applications, including mammalian cells, RBC, WBC, yeast and more. It is the ONLY automated system that is also able to reliably measure particles with an average diameter as small as 3 microns.

Designed to overcome the tedium associated with hemocytometers, the lack of repeatability with image-based counting systems, and the high complexity and expense of Coulter counters and flow cytometers, the Moxi Z OS 4.4 is truly an automated cell counter in a class of its own.

Accelerating Biotherapeutic Discovery | Understanding Pathways | Elucidating Mechanism

Easy access to SPR to help scientists uncover biological processes.

Label-free testing requires little to no sample preparation and, thanks to a compact design, can be performed at your bench. Simultaneous SPR analyses are conducted with three sample channels along with a reference channel. This device is perfect for fundamental research, academic teaching and biotherapeutics quality control.

Core Technology
The P4SPR uses benchmark Kretschmann configuration. The total internal reflection setup enables detection in complex media such as serum, milk or waste water.

Flexible Design
The chip-based P4SPR requires users to inject various solutions to get real-time data. The three-channel sample port provides high-quality data that can be referenced by the fourth channel. For flow sensitive experiments, the P4SPR can easily be fitted to a pump or put inline with another instrument. See our Spec sheet to learn more.

Rapid Data Processing
The P4SPR Control™ software allows for easy data acquisition and processing of P4SPR data. The intuitive data processing method allows users to get a titration curve or affinity data in a very short amount of time.

The RM100 PLUS is the viscometer with the largest speed and torque range available on the market. Create your methods and store your results in relation with your application.

Simple and Convenient Surface Analysis with the Horiba SA-9600 The Horiba SA-9600 series of instruments are ideal for carrying out both single point and multi-point surface area analyses, quickly and simply, on a wide range of powder samples including:
active pharmaceutical ingredients, especially those with low surface areas
a range of catalysts

Meritics are the proud distributors of the NEW MagnoMeter XRS.
Designed for the analysis of complex mixtures using a non-invasive technology focused on dispersed particle surface area analysis.
The analysis of mixtures of materials typically as colloids is difficult and historically mixtures are often defined by their ingredients as once mixed a straightforward analysis is difficult. It is especially important in new engineering materials for use as catalysts, batteries, ink jet printing etc. A key metric in any dispersion is the available wetted surface area, which depends on a variety of factors including: particle size/shape/morphology, surface chemistry and concentration and choice of solvent medium. Intimately related to this is the control of dispersion stability. Monitoring of these properties using a rapid, non-invasive, on-line technique has very clear advantages for product control. Mageleka has developed a new generation Magnometer which measures macroscopic relaxation properties which are sensitive to the various factors above. It also allows for monitoring of the state of a dispersion as well as measurement of diffusion in liquid systems.
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The Pi Raptor Portable, is a full featured particle size and shape analyser enclosed in a ruggedised case for carry-on capability that enables taking a high-resolution particle analyser anywhere. Having a portable system allows for at-site analysis with remote capabilities. The instrument uses Dynamic Image Analysis as a direct measurement technique, which has become more and more common as a Quality Control tool for raw materials in numerous industries. The new “Raptor” architecture offers a large array of improvements in image quality as well as functionality.

The Pi Raptor Portable is designed to operate as a fully functioning Particle Size and Shape Analyser. It can be used at-lab where high quality data and ease-of-use is a requirement and it can also be closed and taken for remote use. The new sample handing capabilities also enable the system to operate for on-line applications.

The Particle Insight Shape Module (PiSM) adds comprehensive particle shape analysis capability to laser diffraction and other size-only wet suspension technologies. Rather than determining only particle size information, the PiSM will report up to 30 different shape-related measures, including size, as well as images of each sample measured.

The SpreadStation Powder Spreadability Analyser measures the spreadability of powders by actually spreading powders in a layer and then analysing the properties of the layer.

Powder is loaded into a spreading device that includes a feeder and a spreading plate. The spreading device rests on a build plate and has an adjustable gap at the bottom to control the powder layer thickness. The build plate is rotated to create linear motion between the spreading device and the build plate. This linear motion spreads the powder in a layer on the build plate.

Images of the created layer are captured and the thickness of the layer is measured using a laser distance sensor. The layer is then removed from the build plate by a scraping blade and is weighed.